Empirical Analysis of Synthesis and Antimicrobial Activities of 1-Methyl-4- Nitro-Imidazole-5-N, N-Diethylsulphonamide
Abstract: There is high level of antimicrobial resistance globally. Most commercial drugs are now becoming ineffective everyday. Hence there is a need to develop new antimicrobial drugs. The aim of the research was to synthesize 1-methyl-4-nitro-imidazole-5-N,N-diethylsulphonamide and determine its antimicrobial activities against bacteria and fungi. N,N′-Dimethyloxamide was synthesized from reaction between diethyl oxalate and methyl amine. The compound became cyclized on reacting with phosphorus (V) chloride to form 1-Methyl-5-chloroimidazole. 1-Methyl-5-chloroimidazole was subjected to nitration using nitric acid and sulphuric acid to give 1-Methyl, 4-nitro-5-chloroimidazole. The treatment of 1-Methyl, 4-nitro-5-chloroimidazole with hydrogen sulphide resulted in the formation of 1-Methyl, 4-nitro-5-thiolimidazole which was converted to 1-Methyl-4-nitro-imidazole-5- sulphonyl chloride. The compound was reacted with diethyl amine leading to the synthesis of 1 methyl-4 nitro-imidazole-5 –N,Ndiethylsulphonamide. Antimicrobial activities of 1-methyl-4-nitro imidazole-5-N, N-diethylsulphonamide was investigated using four bacteria and four plant pathogenic fungi. The results showed that the synthesized compound was active against tested organism, even though the standard used was more active.
Keywords: 1-methyl-4-Nitro-Imidazole-5-N: N-diethylsulphonamide: Antimicrobial: Pathogenic: Nitration: Imidazole: Aromatic Heterocycle
